Hepatocyte
간세포
두 가지 전사인자 OCT4와 HNF4α를 이용해 체세포로부터 제작한 직접교차분화 기술기반 간세포.
Direct Conversion Tech.-based hepatocyte by using two transcription factors; OCT4 and HNF4α.
구성 | 1 vial |
---|---|
세포 Passage | Passage 2 |
1 vial당 세포 수 | ≥ 5x105 cells/vial |
권장 Passage | ~ Passage 7 |
보관 온도 | Liquid Nitrogen |
권장 보관 기간 | ~ 6 months |
Immunofluorescence images of iHepSC-HEP expressing hepatocyte markers (α-fetoprotein: Afp; Albumin: Alb; E-cadherin: E-cad). Scale bar: 150 μm
(Ref. Myung Rae Park, Hyunah Lee, Hans R. Schöler, Jeong Beom Kim, et al. Oct4 and Hnf4α-induced hepatic stem cells ameliorate chronic liver injury in liver fibrosis model. PLOS ONE (2019))
Motor Neuron
운동신경세포
두 가지 전사인자 POU5F1(OCT4) 와 LHX3를 도입해 체세포로부터 제작한 직접교차분화 기술기반 운동신경세포.
Direct Conversion Technology-based motor neuron by using two transcription factors; POU5F1(OCT4) and LHX3.
구성 | 1 vial |
---|---|
세포 Passage | Passage 2 |
1 vial당 세포 수 | ≥ 5x105 cells/vial |
권장 Passage | ~ Passage 7 |
보관 온도 | Liquid Nitrogen |
권장 보관 기간 | ~ 6 months |
Immunofluorescence images of HB9:GFP+ iMNs co-expressing MN specific markers (NKX6.1, TUJ1, MAP2, ISLT1, HB9 and CHAT). Scale bars, 125 μm.
(Ref. Hyunah Lee, Hans R Schöler, Jeong Beom Kim, et al. Sequentially induced motor neurons from human fibroblasts facilitate locomotor recovery in a rodent spinal cord injury model. ELIFE (2020))
Oligodendrocyte
희소돌기아교세포
한 가지 전사인자 OCT4를 도입해 체세포로부터 제작한 직접교차분화 기술기반 희소돌기아교세포.
Direct Conversion Technology-based oligodendrocyte by using a transcription factor; OCT4.
구성 | 1 vial |
---|---|
세포 Passage | Passage 2 |
1 vial당 세포 수 | ≥ 5x105 cells/vial |
권장 Passage | ~ Passage 7 |
보관 온도 | Liquid Nitrogen |
권장 보관 기간 | ~ 6 months |
Expression of the premyelinating oligodendrocytes markers GalC, mature oligodendrocytes RIP, and MBP and co‐expression of RIP and MBP at late stage of maturation of iOPC clones (P5). Scale bars, 75 μm.
(Ref. Jeong Beom Kim, Hyunah Lee, et al. Oct4‐induced oligodendrocyte progenitor cells enhance functional recovery in spinal cord injury model. EMBO J (2015))
Endothelial Cell
혈관세포
두 가지 전사인자 ETV2와 FLI1을 도입해 체세포로부터 제작한 직접교차분화 기술기반 혈관세포.
Direct Conversion Technology-based endothelial cell by using two transcription factors; ETV2 and FLI1.
구성 | 1 vial |
---|---|
세포 Passage | Passage 2 |
1 vial당 세포 수 | ≥ 5x105 cells/vial |
권장 Passage | ~ Passage 7 |
보관 온도 | Liquid Nitrogen |
권장 보관 기간 | ~ 6 months |
Immunocytochemistry images of CD31 in iVPC-derived endothelial cells (ECs).
Representative images of Dil-Ac-LDL (Dil acetylated low-density lipoprotein)uptake in iVPC-derived ECs.
(Ref. Soo Yong Park, Hyunah Lee, Jeong Beom Kim, et al. Etv2- and Fli1-Induced Vascular Progenitor Cells Enhance Functional Recovery in Ischemic Vascular Disease Model. ATVB (2020))